کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
321841 | 539842 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment](/preview/png/321841.png)
چکیده انگلیسی
The preferential dopamine D3-agonist pramipexole (4.25±0.38 mg/day) or placebo were added for up to 12 weeks to ongoing antipsychotic treatment for 24 adult patients with DSM-IV schizophrenia or schizoaffective disorder. Pramipexole was generally well-tolerated (82% trial-completion), and yielded greater decreases in PANSS-total scores (drug/placebo = 2.1; p = 0.04), with similar decreases in PANSS positive and negative scores and 6.7-fold greater reduction of serum prolactin concentrations compared to placebo. There were no differences in ratings of mood, cognition or extrapyramidal symptoms, all of which were low at intake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 22, Issue 6, June 2012, Pages 415–418
Journal: European Neuropsychopharmacology - Volume 22, Issue 6, June 2012, Pages 415–418
نویسندگان
James P. Kelleher, Franca Centorrino, Nancy A. Huxley, John A. Bates, Jennifer Kidwell Drake, Samy Egli, Ross J. Baldessarini,