کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
321854 539846 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of age on dopamine D2 receptor availability in striatal subdivisions: A high-resolution positron emission tomography study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Effects of age on dopamine D2 receptor availability in striatal subdivisions: A high-resolution positron emission tomography study
چکیده انگلیسی

The purpose of the present study was to examine the relationship between age and dopamine D2 receptor availability in striatal subdivisions of young and middle-aged healthy subjects using high-resolution positron emission tomography (PET) with [11C]raclopride to better characterize the nature of age-related decrements in striatal D2 receptor availability. Twenty-four healthy volunteers completed 3-Tesla magnetic resonance imaging and high-resolution [11C]raclopride PET scans. The analyses using linear and exponential models revealed that age had a significant negative correlation with D2 receptor availability in the post-commissural putamen (postPU) and that D2 receptor binding in the postPU decreased significantly more with age than in the ventral striatum, suggesting subregional differences in age-related changes in D2 receptor binding. The postPU, which belongs to the sensorimotor striatum, may be particularly vulnerable to the effects of age in young and middle-aged subjects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 21, Issue 12, December 2011, Pages 885–891
نویسندگان
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