کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
322189 539911 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat
چکیده انگلیسی

The effect of intracerebroventricular infusion of galanin and/or the galanin antagonist M35 was studied in the forced swim test. Animals were pre-exposed to water for 15 min 24 h prior to test. Immobility and climbing were assessed during the second, 5 min exposure to water. Rats receiving a single infusion of galanin (3 nmol) displayed a significant increase of immobility. This effect was blocked by co-administration of M35 (1 nmol). M35 alone (1 nmol) produced a significant decrease of immobility. The results further support the hypothesis that galanin may play a role in mood disorders, and that galanin antagonists may represent new candidates for antidepressant treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 17, Issue 1, 1 January 2007, Pages 64–69
نویسندگان
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