کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323048 540475 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Memory enhancement by Tamoxifen on amyloidosis mouse model
ترجمه فارسی عنوان
تقویت حافظه با تاموکسیفن در مدل موش آمیلوئیدوز
کلمات کلیدی
تاموکسیفن ؛ حافظه؛ دوپامین؛ پیچ و خم آب موریس؛ اجتنابی غیرفعال
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• Tamoxifen protected contextual memory and spatial memory.
• It moderately increased acetylcholine in frontal cortex.
• It significantly decreased dopamine metabolism in striatum.

Tamoxifen (TMX) is a selective estrogen receptor modulator (SERM) used in the treatment of breast cancer. Earlier studies show its neuroprotection via regulating apoptosis, microglial functions, and synaptic plasticity. TMX also showed memory enhancement in ovariectomized mice, and protection from amyloid induced damage in hippocampal cell line. These reports encouraged us to explore the role of TMX in relevance to Alzheimer's disease (AD). We report here, the effect of TMX treatment a) on memory, and b) levels of neurotransmitters (acetylcholine (ACh) and dopamine (DA)) in breeding-retired-female mice injected with beta amyloid1–42 (Aβ1–42). Mice were treated with TMX (10 mg/kg, i.p.) for 15 days. In Morris water maze test, the TMX treated mice escape latency decreased during training trials. They also spent longer time in the platform quadrant on probe trial, compared to controls. In Passive avoidance test, TMX treated mice avoided stepping on the shock chamber. This suggests that TMX protects memory from Aβ induced toxicity. In frontal cortex, ACh was moderately increased, with TMX treatment. In striatum, dopamine was significantly increased, 3,4-dihydroxyphenylacetic acid (DOPAC) level and DOPAC/DA ratio was decreased post TMX treatment. Therefore, TMX enhances spatial and contextual memory by reducing dopamine metabolism and increasing ACh level in Aβ1–42 injected-breeding-retired-female mice.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 79, March 2016, Pages 70–73
نویسندگان
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