کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323793 540779 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy
چکیده انگلیسی

Kennedy Disease/Spinal Bulbar Muscular Atrophy (KD/SBMA) is a progressive neurodegenerative disease caused by genetic polyglutamine expansion of the androgen receptor. We have recently found that overexpression of wildtype androgen receptor in skeletal muscle of transgenic mice results in a KD/SBMA phenotype. This surprising result challenges the orthodox view that KD/SBMA requires expression of polyglutamine expanded androgen receptor within motoneurons. Theories relating to the etiology of this disease drawn from studies of human patients, cellular and mouse models are considered with a special emphasis on potential myogenic contributions to as well as the molecular etiology of KD/SBMA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 53, Issue 5, May 2008, Pages 729–740
نویسندگان
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