کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
323805 540784 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
L-type calcium channel blockade attenuates morphine withdrawal: In vivo interaction between L-type calcium channels and corticosterone
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
L-type calcium channel blockade attenuates morphine withdrawal: In vivo interaction between L-type calcium channels and corticosterone
چکیده انگلیسی

Both opioids and calcium channel blockers could affect hypothalamic–pituitary–adrenal (HPA) axis function. Nifedipine, as a calcium channel blocker, can attenuate the development of morphine dependence; however, the role of the HPA axis in this effect has not been elucidated. We examined the effect of nifedipine on the induction of morphine dependency in intact and adrenalectomized (ADX) male rats, as assessed by the naloxone precipitation test. We also evaluated the effect of this drug on HPA activity induced by naloxone. Our results showed that despite the demonstration of dependence in both groups of rats, nifedipine is more effective in preventing of withdrawal signs in ADX rats than in sham-operated rats. In groups that received morphine and nifedipine concomitantly, naloxone-induced corticosterone secretion was attenuated.Thus, we have shown the involvement of the HPA axis in the effect of nifedipine on the development of morphine dependency and additionally demonstrated an in vivo interaction between the L-type Ca2+ channels and corticosterone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 53, Issue 2, February 2008, Pages 351–357
نویسندگان
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