کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3238879 1205976 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Severe osteogenesis imperfecta Type-III and its challenging treatment in newborn and preschool children. A systematic review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
Severe osteogenesis imperfecta Type-III and its challenging treatment in newborn and preschool children. A systematic review
چکیده انگلیسی

Osteogenesis imperfecta (OI) is a group of genetic disorders, of which Type III is the most severe among survivors. The disease is characterised in particular by bone fragility, decreased bone mass and increased incidence of fractures. Other usual findings are muscle hypotonia, joint hypermobility and short stature. Fractures and weak bones may consequently cause limb and spinal deformity and chronic physical disability. Bisphosphonates have revolutionised the treatment of newborn children with severe OI type III. Surgery is still needed in most patients due to high frequency of the fractures. In this systematic review we describe the present state-of-art in treating the most severe type of OI in newborn and preschool children with their bone fractures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Injury - Volume 46, Issue 8, August 2015, Pages 1440–1446
نویسندگان
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