کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
324054 540880 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of ERα is necessary for estradiol's anorexigenic effect in female rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Activation of ERα is necessary for estradiol's anorexigenic effect in female rats
چکیده انگلیسی

While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this effect. While several studies have demonstrated that activation of ERα, but not ERβ, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ERα, but not ERβ, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ERα prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ERα is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.

Research Highlights
► Estradiol decreases food intake in female rats.
► Estradiol's anorexigenic effect is blocked by the ERα antagonist, MPrP.
► Estradiol's anorexigenic effect was not influenced by the ERβ antagonist, PHTPP.
► Activation of ERα is necessary for estradiol's anorexigenic effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hormones and Behavior - Volume 58, Issue 5, November 2010, Pages 872–877
نویسندگان
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