کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3256802 1589424 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Shaping the spectrum — From autoinflammation to autoimmunity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Shaping the spectrum — From autoinflammation to autoimmunity
چکیده انگلیسی


• Inflammatory responses are exerted by components of the innate and the adaptive immune system.
• Autoimmune-inflammatory disorders can be placed within an “immunological spectrum”.
• Recent observations further establish manifold interconnections between innate and adaptive immune responses.
• Deciphering innate and adaptive mechanisms in autoimmune-inflammatory disorders will allow target-directed treatment.

Historically, autoimmune-inflammatory disorders were subdivided into autoinflammatory vs. autoimmune diseases. About a decade ago, an immunological continuum was proposed, placing “classical” autoinflammatory disorders, characterized by systemic inflammation in the absence of high-titer autoantibodies or autoreactive T lymphocytes, at the one end, and autoimmune disorders at the other end. We provide an overview of recent developments and observations, filling in some of the gaps and showing strong interconnections between innate and adaptive immune mechanisms, indicating that disorders from both ends of the immunological spectrum indeed share key pathomechanisms. We focus on three exemplary disorders: i) systemic juvenile idiopathic arthritis representing “classical” autoinflammatory disorders; ii) psoriasis, a mixed pattern disease; and iii) systemic lupus erythematosus, a prototypical autoimmune disease. We summarize scientific observations suggesting that, depending on disease stages and/or duration, individualized treatment targeting innate or adaptive immune mechanisms in disorders from either end of the immunological spectrum may control disease activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 165, April 2016, Pages 21–28
نویسندگان
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