کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3256996 | 1207384 | 2012 | 13 صفحه PDF | دانلود رایگان |
Analysis and mathematical modeling of T-lymphocyte perturbation following administration of granulocyte colony stimulating factor (G-CSF) and two large-scale aphereses are reported. 74 HIV-1 positive antiretroviral-treated individuals were infused with gene- or sham-transduced CD34+ hematopoietic stem cells (HSC) in a Phase II clinical trial. T cell numbers were examined in four phases: 1) during steady state; 2) increases in peripheral blood (PB) following G-CSF administration; 3) depletion post-aphereses and 4) reconstitution post HSC infusion. The present analysis provides the first direct estimate of CD4+ T cell distribution and trafficking in HIV-infected individuals on stable HAART, indicating that CD4+ T lymphocytes in PB represent 5.5% of the pool of CD4+ T lymphocytes that traffic to PB.
► We estimate T lymphocyte distribution and trafficking in HIV-infected subjects.
► We perform mathematical modeling on in-vivo T lymphocyte data.
► Our data is from a recent Phase II clinical trial of an anti-HIV gene therapy.
► We find that CD4+ T cells in peripheral blood represent 5.5% of total CD4+ T cells.
► We provide the first direct in-vivo estimate of T cell distribution during HIV.
Journal: Clinical Immunology - Volume 144, Issue 2, August 2012, Pages 159–171