کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257116 1207392 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered microRNA expression in B lymphocytes in multiple sclerosis: Towards a better understanding of treatment effects
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Altered microRNA expression in B lymphocytes in multiple sclerosis: Towards a better understanding of treatment effects
چکیده انگلیسی

MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. We compared the expression of 1059 miRNAs in B lymphocytes from untreated and natalizumab treated relapsing–remitting multiple sclerosis (RRMS) patients and healthy volunteers (HV). Forty nine miRNAs were down-regulated in untreated MS patients compared with HV. A distinct pattern of 10 differentially expressed miRNAs was found in natalizumab treated patients compared with untreated patients. Two clusters, i.e. miR-106b-25 and miR-17-92, were particularly deregulated. MiRNA–mRNA interaction analysis revealed B cell receptor, phosphatidyl-inositol-3-kinase (PI3K) and phosphatase and tensin homology (PTEN) signaling being the key affected pathways. We discovered deregulated viral miRNAs in untreated patients as compared with HV and natalizumab treated patients, a novel finding that may be related to latency and activation of viruses in MS. Our findings provide first insights into miRNA dependent regulation of B cell function in MS and the impact of a therapy not primarily targeting B cells on this regulation.


► Specific miRNA expression patterns were identified in B cells of MS patients.
► Natalizumab normalized deregulated miRNA expression in B cells of MS patients.
► Deregulation of viral miRNAs in B cells of MS patients is a novel finding.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 144, Issue 1, July 2012, Pages 70–79
نویسندگان
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