کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257166 1207395 2012 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption
چکیده انگلیسی

In a phase I/IIa clinical trial, 17 HIV-1 infected patients, stable on cART, received 4 vaccinations with autologous dendritic cells electroporated with mRNA encoding Tat, Rev and Nef, after which cART was interrupted. Vaccination was safe and feasible. During the analytical treatment interruption (ATI), no serious adverse events were observed. Ninety-six weeks following ATI, 6/17 patients remained off therapy. Although induced and/or enhanced CD4+ and CD8+ T-cell responses specific for the immunogens were observed in most of the patients, we found no correlation with the number of weeks off cART. Moreover, CD4+ T-cell counts, plasma viral load and the time remaining off cART following ATI did not differ from historical control data. To conclude, the vaccine was safe, well tolerated and resulted in vaccine-specific immune responses. Since no correlation with clinical parameters could be found, these results warrant further research in order to optimize the efficacy of vaccine-induced T-cell responses.


► We conduct a phase I/IIa immunotherapy trial in HIV-1 infected volunteers.
► Autologous dendritic cells are electroporated with Tat, Rev and Nef encoding mRNA.
► Vaccination with autologous dendritic cells is safe and well tolerated.
► Vaccination results in induced and/or enhanced HIV-specific T-cell responses.
► Increased HIV-specific T-cell responses do not correlate with clinical outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 142, Issue 3, March 2012, Pages 252–268
نویسندگان
, , , , , , , , , , , , ,