کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257222 1207400 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice
چکیده انگلیسی

Mounting evidence suggests that helminth infections protect against autoimmune diseases. As helminths cause chronic IgE-mediated activation of basophils and mast cells we hypothesized that continuous activation of these cells could prevent diabetes onset in nonobese diabetic (NOD) mice in the absence of infection. Anti-FcεR1 activated basophils and mast cells and resulted in the release of IL-4 and histamine into the bloodstream. Anti-FcεR1-treated NOD mice showed a type 2 shift in insulin-specific antibody production and exhibited significant delays in diabetes onset. IL-4 responses played a partial role as the protective effect of anti-FcεR1 therapy was diminished in IL-4-deficient NOD mice. In contrast, histamine signaling was not required as anti-FcεR1-mediated protection was not reduced in mice treated with histamine receptor blockers. These results demonstrate that anti-FcεR1 therapy delays diabetes onset in NOD mice and suggest that chronic basophil and mast cell activation may represent a new avenue of therapy for Th1-associated autoimmune diseases.


► Anti-FcεR1 activates basophils and mast cells in vitro.
► Anti-FcεR1 injection induces IL-4 and histamine release in vivo.
► Repeated anti-FcεR1 injections protect against Type 1 diabetes in NOD mice.
► Autoimmune protection due to anti-FcεR1 therapy is partially dependent on IL-4.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 141, Issue 2, November 2011, Pages 205–217
نویسندگان
, , , , , , ,