کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3257310 | 1207405 | 2010 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3 Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3](/preview/png/3257310.png)
Pemphigus vulgaris (PV) is a severe autoimmune bullous skin disease and is primarily associated with IgG against desmoglein 3 (dsg3), a desmosomal adhesion protein. In light of the recent association of autoreactive T helper (Th) 2 cells with active PV, the present study sought to relate the occurrence of Th2-regulated dsg3-specific autoantibody subtypes, i.e. IgE and IgG4, in 93 well-characterized PV patients. Patients with acute onset PV (n = 37) showed the highest concentrations of serum IgE and IgG4 autoantibodies, which were significantly lower in PV patients in remission (n = 14). Furthermore, there was a strong correlation between dsg3-reactive IgE and IgG4 in acute onset, but not in chronic active (n = 42) or remittent patients. Additionally, intercellular IgE deposits were detected in the epidermis of acute onset PV. Thus, dsg3-specific IgE and IgG4 autoantibodies are related to acute onset disease which provides additional support to the concept that PV is a Th2-driven autoimmune disorder.
Journal: Clinical Immunology - Volume 134, Issue 3, March 2010, Pages 320–330