Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: Reversing tumor-induced defects

► There are 2 major CD1d-restricted T cell populations ► Both CD1d-restricted T cell subsets can contribute to anti-tumor immunity ► Both CD1d-restricted T cell subsets can “lose” against progressive tumors ► Both CD1d-restricted T cell subsets defects can be reversed ► Improved CD1d-restricted T cell therapies are nearing clinical trials