کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3257446 | 1207415 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A physiological role for inducible FOXP3+ TREG cells : Lessons from women with reproductive failure A physiological role for inducible FOXP3+ TREG cells : Lessons from women with reproductive failure](/preview/png/3257446.png)
We have previously shown a decreased frequency and function of Tregs in women suffering from recurrent spontaneous abortions (RSA). In the current study, we first investigated the expression of FOXP3 after T-cell activation. We observed that expression of FOXP3 in activated PBMCs was already present above baseline before any cell division, indicating that it was induced in cells that were previously negative for this transcription factor. Because RSA women showed a more limited expansion of FOXP3-positive cells, we next assessed the role of IL-2 signaling through STAT5, which is known to be required for generation of inducible Tregs (iTregs). We demonstrated not only that TGF-β and IL-2 were diminished but also that the IL-2–STAT-5 signaling axis was down regulated in RSA women. Finally, in addition to a limited FOXP3+ cells expansion in vitro, iTregs from RSA women showed a strikingly lower suppressor activity.
Journal: Clinical Immunology - Volume 136, Issue 3, September 2010, Pages 432–441