کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257504 1207418 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis
چکیده انگلیسی

The Mer receptor tyrosine kinase is strongly expressed in the glomerulus. We wondered if this molecule might modify immune-mediated glomerular disease through its functions as a receptor for apoptotic cells and immunoregulatory molecule. Mer-knockout (KO) mice showed decreased survival rate and greatly increased proteinuria and serum urea levels compared to wild type (WT) mice by day 3 after injection of NTS. Their glomeruli were hyperplastic and later became necrotic. In the glomerulus of WT mice, a significant increase of Mer expression was observed. Apoptotic bodies were evident in NTS-treated Mer-KO kidneys, but not in normal controls. NTS-treated Mer-KO mice had massive neutrophil infiltration and inflammatory cytokine expression. Mer thus has a critical role in attenuating renal inflammation, both as a receptor for apoptotic cells and as a molecule that downregulates inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 136, Issue 2, August 2010, Pages 236–244
نویسندگان
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