کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257899 1207431 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography
چکیده انگلیسی

The integrin αEβ7 is believed to play a key role in retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. Five common single nucleotide polymorphisms spanning ITGAE, the gene encoding the αE (CD103) unit, were genotyped in 556 sarcoidosis patients and 465 controls. The − 1088 A/G polymorphism was associated with sarcoidosis (P = 0.004). An increased risk of disease was found for homozygous carriers of the A allele vs. carriers of the G allele (P = 0.001, odds ratio = 1.63 [1.22–2.17]). Analysis of lymphocytes from bronchoalveolar lavage and in vitro functional tests showed higher percentages of CD103+CD4+ T cells for the sarcoidosis risk genotype. Radiographic staging at disease outcome revealed prevalence of − 1088 AA genotype in patients with fibrosis (P = 0.01). A higher proportion of CD103+CD4+ T cells and ITGAE − 1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 133, Issue 1, October 2009, Pages 117–125
نویسندگان
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