کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3257970 | 1207435 | 2008 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis](/preview/png/3257970.png)
We had previously observed that treatment utilizing granulocyte–macrophage colony-stimulating factor (GM-CSF) had profound effects on the induction of experimental autoimmune myasthenia gravis (EAMG), a well-characterized antibody-mediated autoimmune disease. In this study, we show that EAMG induced by repeated immunizations with acetylcholine receptor (AChR) protein in C57BL6 mice is effectively suppressed by GM-CSF treatment administered at a stage of chronic, well-established disease. In addition, this amelioration of clinical disease is accompanied by down-modulation of both autoreactive T cell, and pathogenic autoantibody responses, a mobilization of DCs with a tolerogenic phenotype, and an expansion of regulatory T cells (Tregs) that potently suppress AChR-stimulated T cell proliferation in vitro. These observations suggest that the mobilization of antigen-specific Tregs in vivo using pharmacologic agents, like GM-CSF, can modulate ongoing anti-AChR immune responses capable of suppressing antibody-mediated autoimmunity.
Journal: Clinical Immunology - Volume 128, Issue 2, August 2008, Pages 172–180