کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3258192 1207442 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coronary artery aneurysms in patients with hyper IgE recurrent infection syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Coronary artery aneurysms in patients with hyper IgE recurrent infection syndrome
چکیده انگلیسی

Hyper IgE recurrent infection syndrome (HIES, or Job’s syndrome) is a primary immunodeficiency characterized by recurrent skin and lung infections, eczema, elevated serum immunoglobulin E (IgE) levels, and various connective tissue and skeletal system abnormalities including characteristic facies, scoliosis, joint hyperextensibility, retained primary dentition, craniosynostosis, osteopenia, and pathologic fractures. We have identified two patients with aneurysmal coronary artery disease. One was a forty-three-year-old man with HIES and coronary artery aneurysms and ectasia identified on cardiac catheterization following myocardial infarction. The other was a 48-year-old man with coronary artery ectasia–aneurysm identified after cardiac catheterization for evaluation of chest pain. Although connective tissue abnormalities are common in HIES, this is the first report of coronary artery aneurysms in HIES. Further studies are necessary to determine the incidence, pathogenesis, and optimal therapy of these arterial abnormalities in HIES.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 122, Issue 3, March 2007, Pages 255–258
نویسندگان
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