کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3258354 1207450 2007 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decay-accelerating factor attenuates remote ischemia–reperfusion-initiated organ damage
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Decay-accelerating factor attenuates remote ischemia–reperfusion-initiated organ damage
چکیده انگلیسی

Complement activation contributes to the expression of local and remote organ injury in animal models of ischemia–reperfusion (IR). We demonstrate here that a soluble form of decay-accelerating factor (DAF) protects normal C57Bl/6 and autoimmunity-prone B6.MRL/lpr mice subjected to hindlimb IR from remote intestinal and lung injury without affecting the degree of local skeletal muscle injury. In addition, DAF treatment attenuates remote organ injury in mice subjected to mesenteric IR. Soluble DAF allowed the deposition of complement 3 in local and remote injury sites while it limited the presence of terminal membrane attack complex and did not increase animal susceptibility to sepsis. These data provide evidence that soluble DAF might offer clinical benefit to patients suffering remote intestinal or lung damage in response to muscle or other organ injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 124, Issue 3, September 2007, Pages 311–327
نویسندگان
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