کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3258462 | 1207456 | 2007 | 7 صفحه PDF | دانلود رایگان |
We evaluated the anti-Mycobacterium tuberculosis (Mtb) immune responses of HIV patients after long-term successful HAART, presenting > 500 TCD4+ cells/μl, undetectable viral load, and past history of tuberculosis infection (HIV + PPD+, n = 14) or disease (HIV + CTB, n = 17). Their lymphoproliferative and IFN-γ responses were compared with those from HIV-uninfected controls either PPD+ (HIV − PPD+, n = 17) or with past history of pulmonary tuberculosis (n = 15). Most HIV-infected patients presented normal PHA responses while responses to the Mtb recombinant polypeptides ESAT-6 and Ag85B were markedly reduced. Responses to a whole Mtb lysate (S-Mtb) in HIV + PPD+ patients were lower than in HIV − PPD+ controls, while in HIV + CTB patients these responses were similar to that of past-tuberculosis controls. Comparison between the two HIV groups also suggested better S-Mtb responses in those cured from tuberculosis. Thus, while immune responses to single Mtb proteins are depressed even after successful HAART, reactivity to S-Mtb is high, specially in those cured from tuberculosis, possibly as a result of the survival of higher numbers of mycobacteria-specific T cell clones during the immunosuppression phase, which may afford sufficient protection against new Mtb challenges.
Journal: Clinical Immunology - Volume 125, Issue 1, October 2007, Pages 60–66