کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3258558 1207462 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lysophosphatidic acid enhances antimycobacterial activity both in vitro and ex vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Lysophosphatidic acid enhances antimycobacterial activity both in vitro and ex vivo
چکیده انگلیسی

Lysophosphatidic acid (LPA) is a polar lipid metabolite which is involved in a wide range of biological processes, including cell proliferation and migration, wound healing, and increase of endothelial permeability. The present study reports evidences showing that LPA is able to enhance the antimicrobial activity of human macrophages and of bronchoalveolar lavage cells from tuberculosis patients leading to intracellular growth control of Mycobacterium tuberculosis. Such antimicrobial activity is mediated by the activation of phospholipase D which in turn induces acidification of M. tuberculosis containing phagosomes and is associated with the enhanced expression of Cathepsin D. These results suggest the possible protective role of this lysophospholipid in the activation of innate antimycobacterial response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 121, Issue 1, October 2006, Pages 23–28
نویسندگان
, , , , , , , , ,