کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3258903 1589434 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus
چکیده انگلیسی

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by production of antinuclear autoantibodies and diverse array of clinical manifestations. T cells from patients with SLE have been shown to be activated in vivo and provide help to autoreactive B cells. Lupus T cells exhibit enhanced spontaneous and diminished activation-induced apoptosis and predisposition to necrosis. Persistent mitochondrial hyperpolarization and ATP depletion – associated with significantly increased mitochondrial mass – characterize T lymphocyte dysfunction in SLE. In addition to cell death abnormalities, mitochondrial dysfunction is associated with altered signal transduction through the T cell receptor and Ca2+ fluxing. Exposure of normal T cell to nitric oxide induces mitochondrial hyperpolarization and biogenesis and regenerates the Ca2+ signaling profile of lupus T cells. This article reviews a novel understanding of the role of nitric oxide in signal transduction and cell death abnormalities in SLE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 118, Issues 2–3, February–March 2006, Pages 145–151
نویسندگان
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