کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3258920 1589434 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammatory modulation of PPARγ expression and activity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Inflammatory modulation of PPARγ expression and activity
چکیده انگلیسی

Nitric oxide (NO) production increases with age in the lupus-prone MRL/lpr mouse, paralleling disease activity. One mechanism for excess NO production in MRL/lpr mice may be a defect in down-regulatory mechanisms of the iNOS pathway. A potential modulator of NO is the nuclear hormone receptor peroxisome proliferation activated receptor gamma (PPARγ). We demonstrate that renal PPARγ protein expression was altered as disease progressed in MRL/lpr mice, which paralleled increased iNOS protein expression. Additionally, MRL/lpr-derived primary mesangial cells expressed less PPARγ than BALB/c mesangial cells and produced more NO in response to LPS and IFNγ. Furthermore, PPARγ activity was reduced in mesangial cells following exposure to inflammatory mediators. This activity was restored with the addition of a NOS enzyme inhibitor. These results indicate that the activation of inflammatory pathways may lead to reduced activity and expression of PPARγ, further exacerbating the disease state.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 118, Issues 2–3, February–March 2006, Pages 276–283
نویسندگان
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