کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3258937 1207482 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fcγ-receptor IIA genotype and invasive pneumococcal infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Fcγ-receptor IIA genotype and invasive pneumococcal infection
چکیده انگلیسی
Streptococcus pneumoniae is a major cause of pneumonia, bacteraemia, meningitis, and acute otitis media, especially in young children, immunocompromised patients, and elderly. Fcγ-IIA receptor plays a crucial role in the phagocytosis of IgG2-opsonized bacteria since it is the sole receptor able to interact with IgG2 antibodies. Fcγ-RIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. In a prospective study, we genotyped Fcγ-RIIA in 55 Caucasian patients suffering from invasive pneumococcal disease and in 100 Caucasian controls. In contrast to previous reports, we found no association between Fcγ-RIIA genotype and invasive pneumococcal disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 118, Issue 1, January 2006, Pages 20-23
نویسندگان
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