کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
326615 542478 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Evidence of association of KIBRA genotype with episodic memory in families of psychotic patients and controls
چکیده انگلیسی

The first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer’s disease. Since impaired neurocognitive performance, including memory, may be both a core feature of schizophrenia and a candidate endophenotype, we attempted to replicate this association in a total sample of 544 subjects (including patients with psychosis, their unaffected relatives as well as normal individuals). In the combined sample there was a significant association between the KIBRA T allele and better performance in the single principle component of the memory measures, which included immediate and delayed logical and visual memory from the Wechsler Memory Scale (p = 0.019). In the unaffected individuals (patients’ relatives and healthy controls) we observed an association of KIBRA with immediate and delayed logical memory (p = 0.020 and 0.025, respectively), while in patients with psychosis with delayed visual memory (p = 0.05). This study replicates the association between the KIBRA gene and episodic memory and suggests a possibly differential effect of the polymorphism in psychotic and non-psychotic individuals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 44, Issue 12, September 2010, Pages 795–798
نویسندگان
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