کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3277326 1208612 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study
چکیده انگلیسی

ObjectiveSystemic inflammation may play an important role in the development of atherosclerosis, type 2 diabetes, and some cancers. Few studies have comprehensively assessed the direct relations between dietary fiber and inflammatory cytokines, especially in minority populations. Using baseline data from 1958 postmenopausal women enrolled in the Women's Health Initiative Observational Study, we examined cross-sectional associations between dietary fiber intake and markers of systemic inflammation (including serum high-sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], and tumor necrosis factor-α receptor-2 [TNF-α-R2]) in addition to differences in these associations by ethnicity.MethodsMultiple linear regression models were used to assess the relation between fiber intake and makers of systemic inflammation.ResultsAfter adjustment for covariates, intakes of dietary fiber were inversely associated with IL-6 (P values for trend were 0.01 for total fiber, 0.004 for soluble fiber, and 0.001 for insoluble fiber) and TNF-α-R2 (P values for trend were 0.002 for total, 0.02 for soluble, and <0.001 for insoluble fibers). Although the samples were small in minority Americans, results were generally consistent with those found among European Americans. We did not observe any significant association between intake of dietary fiber and hs-CRP.ConclusionThese findings lend support to the hypothesis that a high-fiber diet is associated with lower plasma levels of IL-6 and TNF-α-R2. Contrary to previous reports, however, there was no association between fiber and hs-CRP among postmenopausal women. Future studies on the influence of diet on inflammation should include IL-6 and TNF-α-R2 and enroll participants from ethnic minorities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 24, Issue 10, October 2008, Pages 941–949
نویسندگان
, , , , , , , , , , , ,