کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3281712 | 1209130 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Primary Sclerosing Cholangitis: Diagnosis, Prognosis, and Management
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کلمات کلیدی
Primary sclerosing cholangitis (PSC)UDCACA19-9AIHMRCPCCAPSCIBDEndoscopic retrograde cholangiopancreatography - cholangiopancreatography رتروگراد endoscopiccarbohydrate antigen 19-9 - آنتی ژن کربوهیدرات 19-9Ursodeoxycholic acid - اورسودوکسی کولیک اسید، اورسودیولInflammatory bowel disease - بیماریهای التهابی رودهmagnetic resonance cholangiopancreatography - تشدید مغناطیسی cholangiopancreatographyColorectal cancer - سرطان روده بزرگfluorescence in situ hybridization - فلورسانس در هیبریداسیون در محلFish - ماهیAutoimmune hepatitis - هپاتیت اتوایمیونLiver transplantation - پیوند کبدCRC - کد افزونگی دورهای Primary sclerosing cholangitis - کلانژیت اسکلروئیدی اولیهCholangiocarcinoma - کلانژیوکارسینومایERCP یا endoscopic retrograde cholangiopancreatography - کلانژیوگرافی آندوسکوپیک عقبگرد یا ایآرسیپیUlcerative colitis - کولیت اولسراتیو
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Primary sclerosing cholangitis (PSC) is a chronic immune-mediated disease of the liver of unclear etiology, characterized by chronic inflammation and fibrosis of bile ducts. It primarily affects middle-aged men and is associated with 4-fold increased mortality as compared with an age- and sex-matched population. Progressive biliary and hepatic damage results in portal hypertension and hepatic failure in a significant majority of patients over a 10- to 15-year period from the initial diagnosis. In addition, PSC confers a markedly increased risk of hepatobiliary cancer, including cholangiocarcinoma and gallbladder cancer, as compared with the general population, and cancer is the leading cause of mortality in patients with PSC. It is associated with inflammatory bowel disease in 70% of patients and increases the risk of colorectal cancer almost 10-fold. Despite significant research efforts in this field, the pathogenic mechanisms of PSC are still incompletely understood, although growing evidence supports the role of genetic and immunologic factors. There are no proven medical therapies that alter the natural course of the disease. Thus, liver transplantation is the only available treatment for patients with advanced PSC, with excellent outcomes in this population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 11, Issue 8, August 2013, Pages 898-907
Journal: Clinical Gastroenterology and Hepatology - Volume 11, Issue 8, August 2013, Pages 898-907
نویسندگان
Siddharth Singh, Jayant A. Talwalkar,