کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3284310 | 1209200 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium
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کلمات کلیدی
NCIMZLB-lymphocyte stimulatorBLySLPLDLBCLNHLUCSFNOSNSWUniversity of California San Francisco - دانشگاه کالیفرنیا سان فرانسیسکوNot otherwise specified - در غیر اینصورت مشخص نیستSEER - سرندconfidence interval - فاصله اطمینانDiffuse large B-cell lymphoma - لنفوم سلول B بزرگ سلول بزرگNon-Hodgkin lymphoma - لنفوم غیر هوچکینFollicular lymphoma - لنفوم فولیکولارLymphoplasmacytic lymphoma - لنفوم لنفوپلاستیMarginal zone lymphoma - لنفوم ناحیه لگنNational Cancer Institute - موسسه ملی سرطانodds ratio - نسبت شانس هاNew South Wales - نیو ساوت ولزHepatitis C virus - هپاتیت سیHCV - هپاتیت سی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40-2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68-2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 6, Issue 4, April 2008, Pages 451-458
Journal: Clinical Gastroenterology and Hepatology - Volume 6, Issue 4, April 2008, Pages 451-458
نویسندگان
Silvia De Sanjose, Yolanda Benavente, Claire M. Vajdic, Eric A. Engels, Lindsay M. Morton, Paige M. Bracci, John J. Spinelli, Tongzhang Zheng, Yawei Zhang, Silvia Franceschi, Renato Talamini, Elizabeth A. Holly, Andrew E. Grulich, James R. Cerhan,