کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3284896 | 1209215 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Screening for Liver Fibrosis by Using a Noninvasive Biomarker in Patients With Diabetes
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کلمات کلیدی
GGTPPVNAFLDHCC - HCCγ-glutamyltranspeptidase - γ-گلوتامیل ترانسپپتیدازpositive predictive value - ارزش پیش بینی مثبتNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیconfidence interval - فاصله اطمینانFibrotest - فیبرتستodds ratio - نسبت شانس هاHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Background & Aims: Patients with diabetes are at risk for nonalcoholic fatty liver disease leading to advanced fibrosis, cirrhosis, and liver cancer. We examined the efficacy of a screening strategy with a noninvasive fibrosis biomarker (FibroTest) in patients with diabetes. Methods: We prospectively studied 1131 consecutive patients without a history of liver disease seen for diabetes. The biomarker data were obtained, and patients with presumed advanced fibrosis were reinvestigated by a hepatologist using elastography and, if necessary, ultrasonography, endoscopy, or liver biopsy. Results: The biomarker predicted advanced fibrosis in 63 of 1131 (5.6%) patients. A total of 45 patients was reinvestigated, and advanced fibrosis was confirmed in 32 patients, a 2.8% (32/1131) prevalence of confirmed advanced fibrosis, 5 cases of cirrhosis, and 4 cases of hepatocellular carcinoma. In the population with type 2 diabetes who were 45 years or older, the prevalence of confirmed advanced fibrosis was 4.3% (30/696), and hepatocellular carcinoma was 5.7 of 1000 (4/696). Conclusions: The fibrosis biomarker might be used for the detection of advanced fibrosis in patients with type 2 diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 6, Issue 7, July 2008, Pages 828-831
Journal: Clinical Gastroenterology and Hepatology - Volume 6, Issue 7, July 2008, Pages 828-831
نویسندگان
Sophie Jacqueminet, Pascal Lebray, Rachel Morra, Mona Munteanu, Laure Devers, Djamila Messous, Maguy Bernard, Agnes Hartemann-Heurtier, Francoise Imbert-Bismut, Vlad Ratziu, Andre Grimaldi, Thierry Poynard,