کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285612 | 1209234 | 2006 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: An Update
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کلمات کلیدی
YMDDCHBHBsAgHBeAgALTHCC - HCCα-fetoprotein - α-فتو پروتئینAlanine aminotransferase - آلانین آمینوترانسفرازantibody to hepatitis B core antigen - آنتی بادی به آنتی ژن هسته ای هپاتیت Bantibody to hepatitis B e antigen - آنتی بادی به آنتی ژن هپاتیت Bantibody to hepatitis B surface antigen - آنتی بادی به آنتیژن سطح هپاتیت BHepatitis B surface antigen - آنتی ژن سطحی هپاتیت Binterferon - اینترفرونIFN - اینترفرون هاAFP - تست AFP یا آلفا فیتو پروتئینanti-HBc - ضد HBcAnti-HBe - ضد HBeAnti-HBs - ضد HBsUltrasound - فراصوتHepatitis B e antigen - هپاتیت B آنتی ژنchronic hepatitis B - هپاتیت B مزمن، هپاتیت ب مزمنHBV - هپاتیت بHepatitis C virus - هپاتیت سیHCV - هپاتیت سیpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازhuman immunodeficiency virus - ویروس نقص ایمنی انسانیHIV - ویروس نقص ایمنی انسانی hepatitis B virus - ویروس هپاتیت بیHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: An Update A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: An Update](/preview/png/3285612.png)
چکیده انگلیسی
Chronic hepatitis B (CHB) is an important public health problem worldwide and in the United States, with approximately 25% of patients infected as neonates dying prematurely from cirrhosis or liver cancer. A treatment algorithm for CHB previously developed and published by a panel of United States hepatologists was revised based on new developments in the understanding of CHB, the availability of more sensitive molecular diagnostic testing, the addition of new treatments, and better understanding of the advantages and disadvantages of approved therapies. This updated algorithm is based on available evidence using a systematic review of the scientific literature. Where data are lacking, the panel relied on clinical experience and consensus expert opinion. Serum HBV DNA can be detected at levels as low as 10 IU/mL using molecular assays and should be determined to establish a baseline level before treatment, monitor response to antiviral therapy, and survey for the development of drug resistance. The primary aim of antiviral therapy is durable suppression of serum HBV DNA to the lowest levels possible. The threshold level of HBV DNA for determination of candidacy for therapy is 20,000 IU/mL or more for patients with hepatitis B e antigen-positive CHB. A lower serum HBV DNA threshold of 2000 IU/mL or more is recommended for patients with hepatitis B e antigen-negative CHB, and 200 IU/mL or more for those with decompensated cirrhosis. Interferon alfa-2b, lamivudine, adefovir, entecavir, and peginterferon alfa-2a all are approved as initial therapy for CHB and have certain advantages and disadvantages. Issues for consideration include efficacy, safety, incidence of resistance, method of administration, and cost.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 8, August 2006, Pages 936-962
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 8, August 2006, Pages 936-962
نویسندگان
Emmet B. Keeffe, Douglas T. Dieterich, Steven-Huy B. Han, Ira M. Jacobson, Paul Martin, Eugene R. Schiff, Hillel Tobias, Teresa L. Wright,