کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285956 | 1209252 | 2006 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic Hepatitis B: A Critical Appraisal of Current Approaches to Therapy
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کلمات کلیدی
TDFAASLDALTETVcccDNACHBPEG-IFNHBeAgAdVHBsAgcovalently closed circular DNA - DNA متصل به جنس مخالف بسته شده استAdefovir - آدفوویرalanine transaminase - آلانین ترانس آمینازantibody to hepatitis B core antigen - آنتی بادی به آنتی ژن هسته ای هپاتیت BHepatitis B surface antigen - آنتی ژن سطحی هپاتیت BAmerican Association for the Study of Liver Diseases - انجمن آمریکایی بررسی بیماری های کبدیEntecavir - انکاویرinterferon - اینترفرونPegylated interferon - اینترفرون تقویت شدهIFN - اینترفرون هاtenofovir disoproxil fumarate - تنوفوویر دیوپروکسیل فوماراتanti-HBc - ضد HBcLAM - لامLamivudine - لامیوودینHepatitis B e antigen - هپاتیت B آنتی ژنchronic hepatitis B - هپاتیت B مزمن، هپاتیت ب مزمنHBV - هپاتیت بpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازhepatitis B virus - ویروس هپاتیت بی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Treatment of chronic hepatitis B (CHB) involves a number of complex and controversial issues. Expert opinions may differ from those of practicing hepatologists and gastroenterologists. We aimed to explore this issue further after a critical review of the literature. Methods: A panel of 14 international experts graded the strength of evidence for 16 statements addressing 3 content areas: patient selection, therapeutic end points, and treatment options. Available data relating to the statements were reviewed critically in 3 small work groups. After discussion of each statement with the entire panel, the experts voted anonymously to accept or reject statements based on the strength of evidence and their experience. A total of 241 members of the American Association for the Study of Liver Diseases (AASLD) responded to the same statements and their responses were compared with those of the experts. A discordant response was defined as a difference of more than 20% in any of the 5 graded levels of response (accept or reject) between the 2 groups. Results: With the exception of 2 statements, the experts' responses were relatively uniform. However, the responses of the AASLD members were discordant from the experts in 12 statements, spanning all 3 content areas. Conclusions: Several areas of disagreement on the management of CHB exist between experts and AASLD members. Our results indicate a potential knowledge gap among practicing hepatologists. Better educational efforts are needed to meet the challenge of managing this complex disorder in which even expert opinion occasionally may disagree.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 2, February 2006, Pages 233-248
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 2, February 2006, Pages 233-248
نویسندگان
Robert P. Perrillo, Robert G. Gish, Marion Peters, Emmet B. Keeffe, Alfredo Alberti, Maria Buti, W. Graham E. Cooksley, Michael W. Fried, Stephanos J. Hadziyannis, Yun-Fan Liaw, Nikolai V. Naoumov, Eugene R. Schiff, Chloe L. Thio, Naoky Tsai,