کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3293229 1209816 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
چکیده انگلیسی

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pancreatic cancer research began to change with the identification of pancreatic stellate cells, which produce the pancreatic tumor stroma. There is compelling in vitro and in vivo evidence for the influence of pancreatic stellate cells on pancreatic cancer development; several recent preclinical studies have reported encouraging results with approaches designed to target pancreatic stellate cells and the stroma. We review the background and recent advances in these areas, along with important areas of future research that could improve therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 144, Issue 6, May 2013, Pages 1210–1219
نویسندگان
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