کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3297423 1209884 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes
چکیده انگلیسی
Our data indicate a role of HLA-B*57−restricted CD8+ T-cell responses in mediating spontaneous clearance and evolution in HCV infection, and viral strains containing epitope variants that are less recognized abrogate the protective effects of HLA-B*57. The finding that HLA-B*57−mediated antiviral immunity is associated with control of both human immunodeficiency virus−1 and HCV suggests a common shared mechanism of a successful immune response against persistent viruses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 140, Issue 2, February 2011, Pages 686-696.e1
نویسندگان
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