کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3300051 1209951 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Critical role of interleukin 5 and eosinophils in concanavalin A–induced hepatitis in mice ★
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Critical role of interleukin 5 and eosinophils in concanavalin A–induced hepatitis in mice ★
چکیده انگلیسی

Background & Aims: Eosinophils are observed in several liver diseases, but their contribution in the pathogenesis of these disorders remains poorly investigated. Concanavalin A (Con A)–induced hepatitis is an experimental model of immune-mediated liver injury in which natural killer T (NKT) cells play a critical role through the production of interleukin (IL)-4 and the expression of Fas ligand (FasL). Because activated NKT cells also produce IL-5, a critical cytokine for eosinophil maturation and function, the role of IL-5 was investigated in this model. Methods: IL-5–deficient mice, eosinophil depletion in wild-type (WT) mice, and NKT cell transfer from WT- or IL-5–deficient mice into NKT cell–deficient mice were used to assess the role of IL-5 and eosinophils. Results: Liver eosinophil infiltrate and IL-5 production were observed after Con A challenge. Liver injury was dramatically reduced in IL-5–deficient or eosinophil-depleted mice. In addition, residual hepatitis observed in Fas-deficient mice was abolished after IL-5 neutralization. Finally, we showed that NKT cells constituted a critical source of IL-5. Indeed, transfer of WT NKT cells to mice lacking NKT cells restored liver injury, whereas transfer of IL-5–deficient NKT cells did not. Conclusions: These observations highlight the pathologic role of IL-5 and eosinophils in experimental immune-mediated hepatitis.GASTROENTEROLOGY 2002;122:2001-2010

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 122, Issue 7, June 2002, Pages 2001–2010
نویسندگان
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