کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328090 1212295 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomere length and human telomerase reverse transcriptase (hTERT) level in patients with acute myeloid leukemia: Impact on clinical outcome
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Telomere length and human telomerase reverse transcriptase (hTERT) level in patients with acute myeloid leukemia: Impact on clinical outcome
چکیده انگلیسی

The response to treatment and overall survival of patients with AML is heterogeneous. Prognostic factors are urgently needed in order to be able to better predict treatment outcomes. The aim of the present work was to study telomere length and human telomerase reverse transcriptase (hTERT) level in acute myeloid leukemia and to detect if these parameters might be useful in providing insight into the clinical outcome of AML patients. ELISA technique was used to measure hTERT level quantitative PCR for measuring telomere length. The study included 70 individuals, 50 patients with acute myeloid leukemia and twenty healthy individuals with comparable age and sex. There was statistically significant higher level of hTERT and lower RTL in patients than controls. The patients were treated according to the standard chemotherapy protocol for induction and they were followed up by bone marrow examination. Mean hTERT level in patients who did not achieve complete hematological remission was statistically significant higher than that in patients who achieved complete hematological remission (48.87 and 34.32 respectively) (z = −1.98, p = 0.048). Mean RTL in patients who achieved remission was higher than that in patients who did not achieve remission (0.56 and 0.37 respectively). However, it did not reach statistical significance. Median survival time in patients who achieved remission was statistically significant longer than that in those who did not achieve remission (26 ms and 4 ms respectively).It was found that both relative telomere length and hTERT could be used for assessing clinical behavior and predicting treatment outcome in AML patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 46, Issue 4, September 2015, Pages 304–311
نویسندگان
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