کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328142 | 1212300 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PrzewlekÅa biaÅaczka limfocytowa u ludzi starszych
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
analogi purynrytuksymabPurine nucleoside analogs - آنالوگهای نوکلئوزید پورینprzeciwciała monoklonalne - آنتیبادیهای مونوکلونالnowe leki - داروهای جدیدNew agents - عوامل جدیدprzewlekła białaczka limfocytowa - لوسمی لنفوسیتی مزمنChronic lymphocytic leukemia - لوسمی مزمن لنفوئیدیMonoclonal antibodies - پادتنهای تَکتیرهChlorambucil - کلمبوچییل
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chronic lymphocytic leukemia (CLL) is predominantly a disease of the elderly, with a median age at diagnosis of 70 years. However, the definition of a cut-off point for a patient to be considered elderly is an important issue. The majority of epidemiological studies and clinical trials use a cut-off point of 65 or 70 years to select the elderly population for this leukemia, but more than half of the patients who require therapy are older than 70 years of age. Advanced age has consistently been associated with a poor prognosis in patients with CLL, predominantly due to the frequent occurrence of co-morbid conditions. Such concerns may result in a less aggressive therapeutic approach. Performance status, biological age and number, severity of comorbid conditions should be incorporated into decision-making process with regard to intensity of treatment. Elderly and/or comorbid patients with CLL may not tolerate more aggressive approach due to high risk of unacceptable toxicity of purine nucleoside analogs, especially in combination with cyclophosphamide and rituximab. Therefore in this patient population, chlorambucil is still accepted as the first-line treatment and this agent remains the backbone of treatment against which the new protocols should be tested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 44, Issue 2, AprilâJune 2013, Pages 93-98
Journal: Acta Haematologica Polonica - Volume 44, Issue 2, AprilâJune 2013, Pages 93-98
نویسندگان
Tadeusz Robak,