کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328172 | 1212302 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Osoczowe stÄżenie cytokin limfo-i angiogennych u chorych na chÅoniaka rozlanego z dużych komórek B
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Angiogenesis and lymphangiogenesis play an important role in the development of diffuse large B-cell lymphoma (DLBCL). Above phenomena are controlled by a number of cytokines among them the most important are vascular endothelial growth factor family members (VEGF), their receptors (VEGF-R) and basic fibroblast growth factor (bFGF). The aim of this study was to evaluate the plasma level of VEGF-C, VEGF-D, VEGF-R3 and bFGF in 55 patients with DLBCL before treatment as well as after chemotherapy with R-CHOP protocol. Control group consisted of 30 healthy subjects. The concentration of VEGF-R3 was significantly higher in patients before treatment than in control group. Concentrations of VEGF-R3 and VEGF-C were significantly higher in patients with higher risk (IPI 3-5) than in subjects with lower risk (IPI 0-2). Additionally, VEGF-R3 was positively correlated with β2-microglobulin, whereas VEGF-D was correlated positively with LDH and β 2-microglobulin, and negatively with platelets count and serum albumins concentration. We found no statistical differences between cytokine values after treatment as compared to initial ones. However, our results do not indicate a predictive value of the cytokines studied regarding the issue of DLBCL therapy, they may suggest a role of some lymphangiogesis-involved factors in the disease activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 43, Issue 3, 2012, Pages 277-284
Journal: Acta Haematologica Polonica - Volume 43, Issue 3, 2012, Pages 277-284
نویسندگان
Wosztyl Anna, WoÅowiec Dariusz, ZióÅkowska Ewelina, Robak Ewa, Korycka-WoÅowiec Anna,