کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328342 1212308 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cereblon: molekularny cel leków immunomodulujących
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Cereblon: molekularny cel leków immunomodulujących
چکیده انگلیسی
Molecular background of complex biological effects of immunomodulatory drugs (IMiDs) thalidomide, lenalidomide and pomalidomide has been largely unknown. Recently, a role of cereblon (CRBN) as a common molecular target for IMiDs and protein crucial for teratogenicity of thalidomide, as well as anti-proliferative, anti-angiogenic and immunomodulatory effects of IMiDs, has been elucidated. In this paper we review published pre-clinical and clinical data on the significance of CRBN expression. Moreover, we discuss perspectives on clinical application of evaluation of CRBN for individualization and monitoring of IMiDs-based therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 44, Issue 3, July–September 2013, Pages 200-207
نویسندگان
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