کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328471 | 1212310 | 2012 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Znaczenie receptora programowanej Åmierci 1 oraz jego ligandów w ukÅadzie immunologicznym oraz nowotworach
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Znaczenie receptora programowanej Åmierci 1 oraz jego ligandów w ukÅadzie immunologicznym oraz nowotworach Znaczenie receptora programowanej Åmierci 1 oraz jego ligandów w ukÅadzie immunologicznym oraz nowotworach](/preview/png/3328471.png)
چکیده انگلیسی
programmed death-1 (pD-1) molecule is an immunoreceptor, which is inducibly expressed on both T and B lymphocytes. pD-1 is a negative regulator of the immune response. Through interactions with its ligands: pD-L1 and pD-L2, being expressed on wide range of tissue, pD-1 is responsible for maintenance of peripheral tolerance by restricting activation, proliferation and effector functions of T lymphocytes. Aberrations of the pD-1/pD-L pathway lead to autoimmune disorders and are observed on exhausted lymphocytes during chronic infections. Expression of pD-1 and its ligands is described in many tumor entities, where it modulates tumor microenviroment and might be a potential escape mechanism from immunosurveillance. There are growing evidences for potential therapeutical applications of the pD-1/pD-L pathway, including heamatological malignances.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 43, Issue 2, Part A, MayâAugust 2012, Pages 132-145
Journal: Acta Haematologica Polonica - Volume 43, Issue 2, Part A, MayâAugust 2012, Pages 132-145
نویسندگان
Maciej Grzywnowicz, Krzysztof (Dr hab.),