کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328474 1212310 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aktywność proteasomu 20S w osoczach pacjentów z nowo rozpoznanym szpiczakiem plazmocytowym
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Aktywność proteasomu 20S w osoczach pacjentów z nowo rozpoznanym szpiczakiem plazmocytowym
چکیده انگلیسی
The purpose of the study is to determine the 20S proteasome ChT-L activity in patients with newly diagnosed multiple myeloma (MM). the 20S proteasome ChT-L activity was assayed using the fluorogenic peptide substrate Suc-Leu-Leu-Val-Tyr-AMC in the presence of an artificial activator sodium dodecyl sulfate (SDS) in the plasma of healthy donors (n = 20) and MM patients (n = 41). The 20S proteasome ChT-L activity was higher in the plasma of MM patients at the diagnosis than in healthy subjects (median 1.24 U/mg; range 0.67-3.61 U/mg vs median 1.09 U/mg; range 0.67-1.62 U/mg). The highest 20S proteasome ChT-L activity was observed at 3rd iss score and the difference was statistically significant (median 1.25 U/mg vs median 1.09 U/mg; p = 0.048). Statistically significant correlations was found between 20S plasma ChT-L activity and β2-microglobulin level (p = 0.007) as well as between 20S plasma ChT-L activity and creatinine concentration (p = 0.019). The plasma 20S proteasome ChT-L activity did not correlate with age and did not depend on the gender of the patients. the results of the study point to usefulness of the 20S proteasome ChT-L activity measurement as a prognostic factor in MM patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 43, Issue 2, Part A, May–August 2012, Pages 155-159
نویسندگان
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