کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328580 1212325 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An update on molecular biology and drug resistance mechanisms of multiple myeloma
ترجمه فارسی عنوان
به روز رسانی در مورد زیست شناسی مولکولی و مکانیزم های مقاوم در برابر دارو میلوم چندگانه
کلمات کلیدی
میلوما چندگانه، جنبه های مولکولی، مقاومت در برابر مواد مخدر، تحویل دارو هدفمند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی


• Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy.
• Development of MM involves a series of complex molecular events, including chromosomal abnormalities, oncogene activation and growth factor dysregulation.
• MM is a difficult disease to treat because of its marked resistance to chemotherapy.
• This review deals with the molecular aspects of MM, drug resistance mechanisms during treatment and also possible new applications for overcoming drug resistance.

Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African–American population. There are several factors to this, such as obesity, environmental factors, family history, genetic factors and monoclonal gammopathies of undetermined significance (MGUS) that have been implicated as potentially etiologic. Development of MM involves a series of complex molecular events, including chromosomal abnormalities, oncogene activation and growth factor dysregulation. Chemotherapy is the most commonly used treatment strategy in MM. However, MM is a difficult disease to treat because of its marked resistance to chemotherapy. MM has been shown to be commonly multidrug resistance (MDR)-negative at diagnosis and associated with a high incidence of MDR expression at relapse. This review deals with the molecular aspects of MM, drug resistance mechanisms during treatment and also possible new applications for overcoming drug resistance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 96, Issue 3, December 2015, Pages 413–424
نویسندگان
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