کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3328586 | 1212325 | 2015 | 15 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Second-line treatment in inoperable pancreatic adenocarcinoma: A systematic review and synthesis of all clinical trials Second-line treatment in inoperable pancreatic adenocarcinoma: A systematic review and synthesis of all clinical trials](/preview/png/3328586.png)
• Use of second-line therapy was reported in 17% of randomised first-line studies.
• Increased rates of second-line therapy correlated with improved overall survival.
• 71 studies of second-line therapy in advanced PDAC were identified.
• Anti-cancer treatment improved survival compared to best supportive care.
• Greater utilisation of second-line chemotherapy in advanced PDAC may improve outcomes.
There remains uncertainty regarding the optimal second-line chemotherapy in advanced pancreatic ductal adenocarcinoma (PDAC). The current recommendation of 5-fluorouracil and oxaliplatin may not be relevant in current practice, as FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan and oxaliplatin) has become a more popular first line therapy in fit patients. The majority of studies in this setting are single-arm Phase II trials with significant heterogeneity of patient populations, treatments and outcomes. In this review, we sought to systematically review and synthesise all prospective data available for the second-line treatment of advanced PDAC.
Journal: Critical Reviews in Oncology/Hematology - Volume 96, Issue 3, December 2015, Pages 483–497