کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328674 1212332 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potentially resectable metastatic colorectal cancer: An individualized approach to conversion therapy
ترجمه فارسی عنوان
سرطان متاستاتیک سرطان کولورکتال ممکن است قابل تنظیم باشد: رویکرد فردی برای تبدیل درمان
کلمات کلیدی
تبدیل درمانی، سرطان روده بزرگ، متاستاز سرطان کولورکتال، متاستازکتومی، درمان های هدفمند، شیمی درمانی، رزاق
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی


• Patients with metastatic colorectal cancer may benefit from radical surgery.
• Conversion therapy is essential for the possible shift from unresectable to resectable disease.
• A tailored approach is possible considering patient and disease's factors.
• Patients presenting with colorectal cancer metastases should be evaluated for multimodal management with curative intent.

Colorectal cancer is one of the most common cancers worldwide. In recent years, the survival of patients with metastatic disease has improved due to the developments in both medical and surgical care. Patients with technically unresectable metastatic disease could benefit from a multidisciplinary approach for their possible shift toward a technically resectable condition; the choice of the most effective systemic treatment is then crucial to allow conversion to resectability. Systemic conversion therapy may include chemotherapy agents’ combinations (fluoropyrimidine, irinotecan and oxaliplatin), with or without targeted agents (cetuximab, panitumumab, bevacizumab). The choice of the best treatment option has to be evaluated by taking into account each patient's baseline characteristics, biological and pathological information and surgical strategy. In particular, the role of some biologic characteristics of the disease, namely the mutational status of EGFR-pathway oncogenes, is emerging as an important predictive factor of response to anti-EGFR targeted agents. Patients presenting with colorectal cancer metastases should be evaluated for multimodal management with curative intent as the appropriate chemotherapy regimen may induce tumor shrinkage, conversion to resectability and improved survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 92, Issue 3, December 2014, Pages 218–226
نویسندگان
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