کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328717 | 1212336 | 2014 | 10 صفحه PDF | دانلود رایگان |
• The management of metastatic ACC is challenging and effective systemic treatments are lacking.
• The molecular characterization of ACC may help to understand the pathogenesis and to define novel therapeutics.
• In this manuscript we reviewed the advances in the therapy of advanced ACC.
Adrenocortical cancer is a rare malignancy. While surgery is the cornerstone of the management of localized disease, metastatic disease is hard to treat. Cytotoxic chemotherapy and mitotane have been utilized with a variable degree of benefit and few long-term responses. A growing understanding of the molecular pathogenesis of this malignancy as well as multidisciplinary and multi-institutional collaborative efforts will result in better defined targets and subsequently, effective novel therapies.
Journal: Critical Reviews in Oncology/Hematology - Volume 92, Issue 2, November 2014, Pages 123–132