کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328771 1212347 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetics in focus: Pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Epigenetics in focus: Pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents
چکیده انگلیسی

Dysregulation of cellular epigenetic machinery is considered a major pathogenetic determinant in many malignancies, including myelodysplastic syndromes (MDS). The importance of epigenetic dysfunction in MDS is reflected by the success of hypomethylating agents as standard of care for their treatment. Although these agents improve both survival and quality of life, knowledge gaps remain regarding the precise role of epigenetics in the pathogenesis of MDS and mechanisms by which hypomethylating agents exert their clinical effects. This article reviews the pathogenic role of epigenetic alterations in MDS, including the relationship between genetic and epigenetic abnormalities, and highlights emerging evidence that hypomethylating agents may reprogram the “methylome” while re-establishing hematopoiesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 88, Issue 2, November 2013, Pages 231–245
نویسندگان
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