کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3329163 | 1590722 | 2011 | 16 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cytogenetic abnormalities in adult non-promyelocytic acute myeloid leukemia: A concise review Cytogenetic abnormalities in adult non-promyelocytic acute myeloid leukemia: A concise review](/preview/png/3329163.png)
Cytogenetic abnormalities are found in 50–60% of newly diagnosed acute myeloid leukemia (AML) of adult patients. Cytogenetic analysis of bone marrow leukemic cells is an important pre-treatment evaluation for a correct prognostic stratification of patients, that permit to separate AML patients in three broad prognostic categories: high, intermediate and low risk. The determination of cytogenetic features of AML remains a corner stone in predicting outcome although today its use needs to be integrated by molecular and immunophenotypic data, particularly in cytogenetically normal (CN) group of patients.In this review we perform a concise description of more recurrent cytogenetic aberrations found in AML, theirs correlations with biological and clinical data and theirs strong impact with outcome of patients, useful for therapeutic decision.
Journal: Critical Reviews in Oncology/Hematology - Volume 80, Issue 3, December 2011, Pages 331–346