کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3329178 1212378 2011 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical, laboratory and molecular factors predicting chemotherapy efficacy and toxicity in colorectal cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Clinical, laboratory and molecular factors predicting chemotherapy efficacy and toxicity in colorectal cancer
چکیده انگلیسی

Colorectal cancer (CRC) treatment has evolved significantly over the last ten years with the use of active chemotherapeutic agents including fluoropyrimidines, oxaliplatin and irinotecan plus targeted monoclonal antibodies bevacizumab, cetuximab and panitumumab. The addition of newer chemotherapeutic agents and targeted therapies has improved patient outcomes at the cost of increased toxicity with not all patients benefiting from these treatments. It is necessary for clinicians to more accurately predict clinical outcomes particularly in the predominantly elderly CRC patient population. This review aims to summarise existing data regarding the use of clinical and laboratory variables plus molecular markers in predicting response, survival and toxicity to chemotherapy agents and targeted monoclonal antibodies currently used in the treatment of CRC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 79, Issue 3, September 2011, Pages 224–250
نویسندگان
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