کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3329404 1212394 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pegfilgrastim primary prophylaxis vs. current practice neutropenia management in elderly breast cancer patients receiving chemotherapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Pegfilgrastim primary prophylaxis vs. current practice neutropenia management in elderly breast cancer patients receiving chemotherapy
چکیده انگلیسی

We investigated the incidences of febrile neutropenia (FN) and related complications in elderly (≥65 years) breast cancer patients receiving chemotherapy supported by pegfilgrastim primary prophylaxis (PP; n = 150) or current practice (CP) neutropenia management (n = 104) in a subanalysis of NeuCuP (Neulasta® vs. current practice neutropenia management). Studies involving regimens with moderately high to high (≥15%) FN risk were identified by literature review, and individual patient data were integrated for analysis. FN incidence was 6% (95% CI: 2, 10%) in the PP group and 24% (95% CI: 16, 32%) in the CP group. In cycle 1, incidences were 3 and 15%, respectively. FN-related hospitalisation incidence was 5% (PP group) and 15% (CP group), while dose reductions (≥15%) occurred in 15 and 29% of patients. Pegfilgrastim provided effective PP in elderly patients, a population who may be vulnerable to chemotherapy-related FN and for whom current practice may not provide adequate protection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 74, Issue 3, June 2010, Pages 203–210
نویسندگان
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